Ceredase (Genzyme Corp)

Ceredase (Genzyme Corp) - General Information

Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Ceredase (Genzyme Corp) is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated with mannose residues

Pharmacology of Ceredase (Genzyme Corp)

Gaucher disease is characterized by a functional deficiency in Beta-glucocerebrosidase enzymatic activity and the resultant accumulation of lipid glucocerebroside in tissue macrophages which become engorged and are termed Gaucher cells. Gaucher cells are typically found in liver, spleen and bone marrow. This can lead to an enlarged spleen and liver (hepatosplenomegaly). Secondary hematologic sequelae include severe anemia and thrombocytopenia. Injections of alglucerase into Gaucher disease patients leads to elevated serum levels of the enzyme and reduction in the accumulation of glucocerebrosid.

Ceredase (Genzyme Corp) for patients

Ceredase (Genzyme Corp) Interactions

Ceredase (Genzyme Corp) Contraindications

There are no known contraindications to the use of Ceredase (alglucerase injection).

Additional information about Ceredase (Genzyme Corp)

Ceredase (Genzyme Corp) Indication: For the treatment of Gaucher's disease (deficiency in glucocerebrosidase)
Mechanism Of Action: Ceredase (Genzyme Corp) catalyzes the hydrolysis of the glycolipid, glucocerebroside, to glucose and ceramide as part of the normal degradation pathway for membrane lipids.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Alglucerase
Synonyms: Acid beta-glucosidase; Beta-glucocerebrosidase; D-glucosyl-N-acylsphingosine glucohydrolase; Glucosylceramidase precursor
Drug Category: Enzyme Replacement Agents
Drug Type: Biotech; Approved

Other Brand Names containing Alglucerase: Ceredase (Genzyme Corp);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 3.6-10.4 min
Dosage Forms of Ceredase (Genzyme Corp): Injection, solution Intravenous drip
Chemical IUPAC Name: Human Beta-glucocerbrosidase
Chemical Formula: C2532H3854N672O711S16
Alglucerase on Wikipedia: https://en.wikipedia.org/wiki/Alglucerase
Organisms Affected: Humans and other mammals